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Partial Tolerant State Against H‐2 Disparate Cells
Author(s) -
JACOBSSON H.,
LILLIEHÖÖK B.,
BLOMGREN H.
Publication year - 1976
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1976.tb03046.x
Subject(s) - immune system , immunology , antibody , antigen , biology , lymphocyte , microbiology and biotechnology
Injection of CBA mice with H‐2‐compatible lymphoid cells from C3H hybrids induces a specific reduction of the mixed lymphocyte culture (MLC) response of their lymphoytes. This is not the case after injection of H‐2‐disparate C3H‐hybrid cells, presumably because they are rapidly eliminated due to the immune response of the host. This investigation shows that CBA mice injected with CBA × C57B1 cells (H‐2‐disparate) at an age of 0–3 days, but not older, develop a specifically reduced MLC response after infusion of C3H × C57B1 cells as adults, indicating that they were tolerant to the C57B1‐determined antigens. However, lymphocytes from such mice showed a normal reactivity against C57B1 as assessed by MLC, graft‐versus‐host tests, and capacity to produce specific antibodies.