Premium
Two Populations of Lymphocytes Involved in Phytohaemagglutinin‐Induced Cytotoxicity of a Dividing Target Cell
Author(s) -
WALLER C. A.,
CAMPBELL A. C.,
MacLENNAN I. C. M.
Publication year - 1976
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1976.tb03044.x
Subject(s) - phytohaemagglutinin , cytotoxic t cell , cytotoxicity , receptor , antibody , surface immunoglobulin , cell , microbiology and biotechnology , biology , immunology , chemistry , in vitro , lymphocyte , b cell , biochemistry
A quantitative study of the surface characteristics of cells cytotoxic against Chang tells permits the following conclusions: [1] In the presence of phytohaemagglutinin two types of cell are involved; one has Fc receptors and the other does not. Approximately two thirds of the cytotoxic activity is lost if the Fc‐receptor‐bearing cells are removed. [2] Both spontaneous and antibody‐induced cytotoxicity is almost completely abolished by removal of Fc‐receptor‐bearing cells. [3] None of the cytotoxic activity, spontaneous or induced, appears to be mediated by cells that are plastic‐adherent or bear surface immunoglobulin. These results are compared with similar studies by other authors.