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Evidence of Oligomeric IgA in Canine Thymus Cysts
Author(s) -
SANDHOLM M.,
KAARTINEN M.,
OKSANEN A.
Publication year - 1976
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1976.tb03001.x
Subject(s) - ultracentrifuge , antibody , sedimentation coefficient , analytical ultracentrifugation , nip , chemistry , population , cyst , pathology , biology , immunology , chromatography , medicine , biochemistry , enzyme , materials science , composite material , environmental health
The content of canine thymic cysts present in involuted thymuses was studied. The major component of the cyst fluid consisted of an electrophoretically heterogeneous molecule population having cross‐reactivity with IgA and a high natural antibody activity against DNP and NIP. The major IgA fraction had a sedimentation coefficient of 10S, suggesting a dimeric form. High natural antibody activity was seen also in the 12S‐16S area on ultracentrifugation, which indicates that polymers larger than dimers also occur. However, semiquantitative analysis showed that dimeric IgA is probably a major component of canine thymic cyst fluid.