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Coexistence of Protein AA and Immunoglobulin Light‐Chain Fragments in Amyloid Fibrils
Author(s) -
WESTERMARK P.,
NATVIG J. B.,
ANDERS R. F.,
SLETTEN K.,
HUSBY G.
Publication year - 1976
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1976.tb02989.x
Subject(s) - immunoglobulin light chain , amyloid fibril , amyloid (mycology) , chemistry , antibody , fibril , amyloidosis , biophysics , amyloid β , biology , biochemistry , medicine , immunology , pathology , disease , inorganic chemistry
Coexistence of amyloid fibril protein AA and homogeneous immunoglobulin light‐chain fragments was found in the isolated amyloid fibrils of two patients with amyloidosis secondary to rheumatoid arthritis. The light‐chain amyloid fibril protein showed antigenic identity with a light‐chain amyloid from a patient with primary amyloidosis, which was identified as the VλIV subgroup by amino acid sequence analysis. In the amyloid fibrils isolated from another patient with primary amyloidosis there was a mixture of VλIV and VλV homogeneous immunoglobulin light chains. Thus, a mixture of protein AA and λ light chains or two different types of homogeneous light chains may be found in the amyloid fibrils of some patients.