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Changes in the Surface of Virus‐Infected Cells Recognized by Cytotoxic T Cells
Author(s) -
ADA G. L,
JACKSON D. C.,
BLANDEN R. V.,
HLA R. THA,
BOWERN N. A.
Publication year - 1976
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1976.tb02988.x
Subject(s) - cytolysis , intracellular , virus , cytotoxic t cell , biology , lysis , ectromelia virus , immune system , cell , virology , mastocytoma , intracellular parasite , immunology , microbiology and biotechnology , biochemistry , in vitro , gene , recombinant dna , vaccinia
P‐815 mastocytoma cells develop susceptibility to immune T‐cell‐mediated cytolysis shortly after infection by ectromelia virus. Intracellular viral replication and late protein synthesis seem to be unnecessary events. Interference with early protein synthesis, however, inhibits the development of susceptibility to lysis. The important intracellular events necessary for subsequent cytolysis appear to occur within 1 hr of infection. Virus rendered noninfectious by ultraviolet irradiation but not by γ irradiation is able to induce these changes. By determining the minimum and essential events of the infectious process which result in T‐cell‐mediated cytolysis, the task of establishing the molecular changes occurring in the target cell surface membrane necessary for immune T‐cell recognition should be simplified.