Premium
IgA in Commercial γ‐Globulin Preparations
Author(s) -
WADSWORTH C.,
HANSON L. Å.
Publication year - 1976
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1976.tb02987.x
Subject(s) - gamma globulin , immunoelectrophoresis , immunoglobulin a , globulin , immunofluorescence , antibody , chemistry , size exclusion chromatography , immunology , immunoglobulin g , medicine , biochemistry , enzyme
The presence of anti‐IgA has been related to adverse reactions to injection Oil infusion of IgA‐containing material. In this study IgA was demonstrated in all of the investigated commercial γ‐globulin preparations. In the material from a few producers it was, however, very low. By immuno‐gel filtration it could be shown that the IgA consisted of aggregates as well as a 7S component and fragments. By immunoelectrophoresis‐immunuofluorescence IgG‐IgA complexes could also be detected. The IgA aggregates could be almost Completely degraded by reduction‐alkylation. It is implied that such changed IgA in γ‐globulin preparations for injection may increase the risk of immunization against IgA.