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Binding of IgM by Human T Lymphocytes
Author(s) -
GMELIGMEYLING F.,
HAM M.,
BALLIEUX R. E.
Publication year - 1976
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1976.tb00303.x
Subject(s) - rosette formation , immunology , antibody , in vitro , lymphocyte , rosette (schizont appearance) , population , biology , human blood , microbiology and biotechnology , chemistry , medicine , biochemistry , physiology , environmental health
Ox etythrocytes, sensitized with IgM‐type rabbit antibodies, were found to form rosettes with human blood lymphocytes. Granulocytes, monocytes, and macrophages appeared to lack this property. The rosette formation could be inhibited with human IgM and its Fc fragments. IgM‐binding lymphocytes were also present in cell suspensions isolated from human tonsils and thymuses and among blood lymphocytes cultured in vitro. The outcome of combined marker tests and cell separation experiments disclosed that the resetting lymphocytes belong to the T‐lymphocyte population.