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Properties of Fcγ Receptors in Normal and Malignant Human Tissues
Author(s) -
MATRE R.,
TÖNDER O.,
THUNOLD S.,
SOLHAUG J. H.
Publication year - 1976
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1976.tb00290.x
Subject(s) - receptor , spleen , chemistry , sodium azide , immune receptor , peripheral blood mononuclear cell , biochemistry , biology , microbiology and biotechnology , immunology , in vitro
Properties of the IgG receptors were studied by treating tissue sections or suspensions of peripheral mononuclear cells with various chemical reagents and determining changes in their ability to react with IgG‐sensitized erythrocytes (EA). A heterogeneity of the Fc receptors was revealed. lodoacetamide, 2‐mercaptoethanol, sodium azide, EDTA, and a pH varying from 6.0 to 8.2 had no effect on Fc receptors in sections of normal lymphoreticular tissue and malignant tissue. Formaldehyde, low pH, and high salt concentrations affected receptor activity to various degrees. Receptors in liver sections and on monocytes were generally more resistant than receptors in spleen sections and on B lymphocytes. Receptors in malignant tissue behaved either like receptors in spleen or like receptors in liver. Although all tissues were sensitive to periodic acid, the Fc receptors in malignant tissue were always more resistant.