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Complex Nature of the Production of ‘Effector Cells and Their Interaction with Target Cells in the M‐Antigen System of the Mouse
Author(s) -
LILLIEHÖÖK B.,
JACOBSSON H.,
BLOMGREN H.
Publication year - 1976
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1976.tb00287.x
Subject(s) - antigen , effector , biology , bone marrow , immunology , microbiology and biotechnology , c57bl/6
The capacity of lymphocytes from mouse strain CBA to generate ‘effector’ cells against the H‐2‐compatible, M‐antigen‐incompatible strain C3H and their interaction with such target cells were investigated. It was observed that CBA lymphocytes injected in, and 5 days later obtained from, the spleens of irradiated C3H × CBA hybrids (‘educated cells’) could strongly inhibit the growth of C3H × CBA bone marrow cells but were almost nonresponsive to C3H × C57BI bone marrow targets (H‐2‐incompatible). CBA lymphocytes educated in irradiated C3H × C57B1 hosts displayed reactivity against C3H × C57B1 and CBA × C57B1 but not against C3H × CBA bone marrow target cells. Additional tests indicated that the M antigen determined by C3H is expressed td approximately the same extent on C3H × CBA and C3H × C57B1 cells and that the M antigen on C3H does not cross‐react immunologically with antigens on C57B1 cells. Moreover, it was observed that CBA × C57B1 lymphocytes were triggered to cell proliferation by C3H antigens but were unable or had a highly reduced capacity to develop ‘effector’ cells in response to this antigenic stimulus. These results indicate that generation of ‘effector’ cells and their interaction with target cells are very complex processes.