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Chemical and Genetic Characterization of a Monoclonal IgA(λ) Protein with Both Cryo‐ and Pyro‐Precipitability
Author(s) -
WANG A. C.,
FUDENBERG H. H.,
WANG I. Y.,
WATANABE A.
Publication year - 1976
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1976.tb00284.x
Subject(s) - glutamine , monoclonal antibody , chemistry , amino acid , biochemistry , immunoglobulin light chain , heavy chain , monoclonal , glutamic acid , antibody , biology , genetics , gene
Studies of a monoclonal IgA(λ) protein with both cryo‐ and pyro‐precipitability show that it belongs to the IgA2 subclass and is positive for the A 2 m(2) allotypic marker. Like other cryoglobulins, this protein also has an unblocked light chain, and its heavy chain belongs to the V H I subgroup. The first 22 N‐terminal amino acids of the λ chain of this protein showed less than 65% homology with those of other human λ chains but showed 86% identity with that of an amyloid fibril protein reported by others. The α chain of this protein appears to have more glutamic acid or glutamine, or both, and less isoleucine residues than other human α chains.