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Distribution of Cells Binding Erythrocyte‐Antibody (EA) Complexes in Human Lymphoid Populations
Author(s) -
SAMARUT C.,
BROCHIER J.,
REVILLARD J. P.
Publication year - 1976
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1976.tb00273.x
Subject(s) - antibody , distribution (mathematics) , biology , immunology , chemistry , mathematics , mathematical analysis
Cells bearing Fc receptors were studied using a rosette technique with chicken erythrocytes coated with rabbit antibodies (EA). By comparison with other markers and by selective depletion of T and B cells it was demonstrated that EA rosettes were formed by about 10% of the monocytes, 7% of the T lymphocytes, and 45% of the B cells. In addition, 26% of EA‐rosette‐forming cells (EA‐RFC) in the peripheral blood carried no other markers than C3 receptors. Marked differences were found in the percentages of EA‐RFC in cell suspensions from various lymphoid organs: peripheral blood, 15.2%; spleen, 26.6%; bone marrow, 30.9%; lymph nodes, 2.8%; thymus, 0.3%; and tonsils, 0.5%. It was concluded that Fc receptors were present on subsets of different lymphocyte sub‐populations; their presence could not be regarded as a specific marker of one of these subpopulations.