Premium
The Effect of Anti‐Immunoglobulin Antibodies on Fc Rosettes
Author(s) -
KRAMMER P. H.,
PERNIS B.
Publication year - 1976
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1976.tb00270.x
Subject(s) - antibody , allotype , fragment crystallizable region , immunoglobulin g , incubation , microbiology and biotechnology , biology , fc receptor , receptor , chemistry , immunoglobulin m , immune system , immunology , biochemistry
This study demonstrated that Fc rosettes detected by antibody‐labeled bovine erythrocytes can be inhibited by immune complexes of rabbit IgG (b4 allotype) and anti‐b4 IgG, thus showing that these complexes effectively compete for the receptor for erythrocyte‐antibody rosettes. Incubation of mouse lymphocytes with goat f (ab′) 2 anti‐mouse IgG did not inhibit Fc rosettes. When immunoglobulin on murine and human B lymphocytes was redistributed in a polar cap on the membrane by interaction with anti‐immunoglobulin antibodies, the number of Fc rosettes after ‘capping’ was unchanged; most of the indicator erythrocytes, however, were distributed in a cap as well. This erythrocyte cap was superimposed on the immunoglobulin cap.