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Suppressor Cell Activity in a Male Infant with T‐ and B‐Lymphocyte Dysfunction Treated with Thymosin
Author(s) -
HANSON L. Å.,
LINDHOLM L.,
CARLSSON B.,
FASTH A.,
FÄLLSTRØM S. P.,
WADSWORTH C.,
VÄRENDH G.
Publication year - 1976
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1976.tb00267.x
Subject(s) - concanavalin a , pokeweed mitogen , lymphocyte , thymosin , immunology , suppressor , in vitro , endocrinology , medicine , biology , biochemistry , cancer
A male infant with bilateral iris coloboma who had had repeated infections and malabsorption was studied. The levels of total lymphocytes and of T Rod B cells were normal or high, but IgA became undetectable and IgG low, whereat IgM was normal. His lymphocytes did not respond to phytohemaggtutinin (PHA), concanavalin A. pokeweed mitogen (PWM) or in mixed lymphocyte reactions (MLR). nor did they respond in vitro when thymosin was included in the test systems, He was skin‐test‐negative, even to dinitrochlorobenzene. His crudely isolated T lymphocytes and the, supernatant of his PHA stimulated lymphocytes inhibited the response of normal lymphocytes to PHA, PWM, and in MLR. During thymosin treatment skin tests and lymphocyte reactivity tit mitogen remained negative. He became faintly positive in MLR, and the suppressor activity in the supernatant of his PUA‐stimulated lymphocytes DO longer inhibited the response of normal lymphocytes to PHA, PWM or in MLR In parallel with thymosin treatment he showed quite marked clinical improvement