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The Effects of Mouse Alpha‐Fetoprotein on T‐Cell‐Dependent and T‐Cell‐Independent Immune Responses In Vitro
Author(s) -
MURGITA R. A.,
WIGZELL H.
Publication year - 1976
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1976.tb00265.x
Subject(s) - concanavalin a , ficoll , microbiology and biotechnology , polyclonal antibodies , antigen , antibody , t cell , immune system , biology , in vitro , dna synthesis , immunology , t lymphocyte , biochemistry , peripheral blood mononuclear cell
Mouse alpha‐fetoprotein (AFP) suppressed the specific antibody response to the T‐cell‐dependent antigen sheep erythrocytes (SRBC) and the phytohemagglutinin‐and concanavalin‐A‐stimulated DNA synthesis of purified T lymphocytes but failed to inhibit the T‐cell‐independent antibody response to dinitrophenyl‐substituted Ficoll (DNP‐Ficoll) and the lipopolysaccharide‐stimulated polyclonal B‐cell antibody synthesis. Mouse amniotic fluid (MAF) suppressed antibody responses to both T‐cell‐dependent and T‐cell‐independent antigens; however, the effects could be differentiated since dialysis of the MAF removed most of the suppressive effect on the DNP‐Ficoll response but did not diminish the inhibitory action on the anti‐SRBC response. The results indicate that AFP suppresses certain T‐lymphocyte functions in vitro and does not act by directly inhibiting B‐cell functions.