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Genetic Control of Antibody Responses to PHA in Inbred Rats
Author(s) -
KOCH C.
Publication year - 1976
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1976.tb00256.x
Subject(s) - biology , antibody response , major histocompatibility complex , antibody , inbred strain , in vitro , antigen , gene , histocompatibility , immunology , genetics , microbiology and biotechnology , human leukocyte antigen
Phytohemagglutinin (PHA‐P; Difco) contains four immunogenic components. The antibody response in rats to two of these components is shown to be genetically determined; AS rats are high responder and BN rats are low responders to both antigens. Responsiveness to the two components segregates independently as autosomal, dominant traits in a manner that is compatible with a one‐gene hypothesis for both responses. The antibody response to the mitogenic fraction of PHA and to other mitogens. These responses are not linked to the major histocompatibility complex (MHC) of the rat. The antibody response to a nonmitogenic fraction from PHA is, however, linked to the MHC.