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IgA Deficiency and Influenza Infection
Author(s) -
AHO K.,
PYHÄLÄ R.,
KOISTINEN J.
Publication year - 1976
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1976.tb00247.x
Subject(s) - radioimmunoassay , antibody , titer , immunodiffusion , immunology , iga deficiency , hemagglutination , radial immunodiffusion , immunoglobulin a , medicine , virology , biology , immunoglobulin g
A prospective study of influenza infection was carried out on 90 blood donors deficient for serum IgA as tested with double immunodiffusion. Half of them lacked IgA even by radioimmunoassay (RIA). A correlation existed between serum haemagglutination‐inhibiting (HI) antibody and resistance to infection, suggesting that the serum HI antibody was an important determinant of protection. The rate of infection as evidenced by a fourfold or greater rise in HI titre, was about the same in the RIA‐negative and RIA‐positive donors and only slightly higher than the corresponding rate in pregnant women and in a ship's crew.