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Lymphocyte Populations and Cellular Immune Reactions in Juvenile Rheumatoid Arthritis
Author(s) -
HØYERAAL H. M.,
FRØLAND S. S.,
WISLØFF F.
Publication year - 1975
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1975.tb03720.x
Subject(s) - immune system , immunology , juvenile rheumatoid arthritis , lymphocyte , rheumatoid arthritis , antibody , arthritis , cytotoxic t cell , in vitro , in vivo , medicine , biology , biochemistry , microbiology and biotechnology
Ten patients with juvenile rheumatoid arthritis and age‐ and sex‐matched healthy controls were investigated in pairs. The patients were found to have both normal proportions and normal absolute numbers of T lymphocytes, B lymphocytes, and the Fc‐receptor‐bearing lymphoid cells in peripheral blood. No abnormality of mitogen‐induced lymphocyte transformation was observed. Lymphocyte‐mediated cytotoxicity induced by phytohemagglutinin (PHA) or anti‐target cell antibodies was also found to be normal. As in an earlier study, impaired delayed hyper‐sensitivity by skin testing was observed in the patient group, thus indicating a dissociation between in vivo and in vitro parameters of lymphoid cell function.