Premium
Blocking Effect of J Chain and J‐Chain Antibody on the Binding of Secretory Component to Human IgA and IgM
Author(s) -
BRANDTZAEG P
Publication year - 1975
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1975.tb02694.x
Subject(s) - secretory component , j chain , antibody , antigenicity , chemistry , blocking (statistics) , immunoglobulin light chain , heavy chain , chain (unit) , component (thermodynamics) , binding site , blocking antibody , microbiology and biotechnology , biochemistry , receptor , biology , immunology , physics , astronomy , thermodynamics , statistics , mathematics
Isolated released J chain showed only a small affinity for free secretory component (SC), as indicated by a marginal but reproducible blocking effect on the binding of SC to Ig polymers. The SC‐binding site was completely blocked by J‐chain antibody in those Ig polymers where the bound J chains were accessible to the antibody. Along with the established masking effect of SC on the antigenicity of J chains present in secretory IgA, these results are compatible with the idea that the conformation of Ig‐associated J chains contributes to the SC‐binding site of Ig polymers.