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The Failure of Allogeneic Cells to Maintain an Immune Response in Nude Mice
Author(s) -
KINDRED B.
Publication year - 1975
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1975.tb02673.x
Subject(s) - congenic , immune system , antigen , biology , immunology , strain (injury) , genetics , gene , anatomy
Nude mice that have been injected with allogeneic thymus cells and sheep erythrocytes respond for a short time and are then unable to respond to subsequent injections of sheep erythrocytes, even if given with allogeneic thymus cells from the same or a different strain. However, they can respond to a different antigen or to the original antigen if given with congenic thymus cells. B cells from such animals are able to respond if transferred together with congenic thymocytes to irradiated hosts. It is suggested that allogeneic T cells are able to cooperate with B cells to initiate an immune response but that a further step is necessary to maintain the response, and for this congenic T cells are necessary.