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Immunoglobulin Synthesis In Vitro by Cerebrospinal Fluid Cells in Patients with Meningoencephalitis of Presumed Viral Origin.
Author(s) -
SANDBERGWOLLHEIM M.
Publication year - 1975
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1975.tb02669.x
Subject(s) - cerebrospinal fluid , meningoencephalitis , polyclonal antibodies , antibody , in vitro , immunoglobulin g , distribution (mathematics) , immunology , virus , pathology , chemistry , virology , biology , medicine , biochemistry , mathematical analysis , mathematics
Cerebrospinal fluid (CSF) cells from six patients with meningoencephalitis ol presumed viral origin were incubated in the presence of labeled amino acids. The cells of two of the patients synthesized IgG, IgA, and IgM (one patient) in vitro The CSF of these two patients had an elevated level of IgG with oligoclonal distribution. The newly synthesized IgG also had an oligoclonal distribution. CSF cells of the other four patients were not shown to synthesize immunoglobulins in vitro. The CSF of these patients had a normal level of IgG with polyclonal distribution. The results demonstrate that in some patients with virus meningoencephalitis an immunoglobulin synthesis takes place locally and that at least part of the IgG shows a restricted heterogeneity. The results also suggest the presence of stimulated lymphocytes in the CSF of the same patients.