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A Surface Antigen Marker for Human Monocytes
Author(s) -
GREAVES M. F.,
FALK J. A.,
FALK R. E.
Publication year - 1975
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1975.tb02661.x
Subject(s) - tonsil , peripheral blood mononuclear cell , antigen , antiserum , monocyte , immunofluorescence , spleen , population , immunology , indirect immunofluorescence , biology , macrophage , mononuclear phagocyte system , cell , microbiology and biotechnology , pathology , antibody , medicine , in vitro , biochemistry , environmental health , genetics
Antisera have been raised in rabbits against human peritoneal macrophages. After absorption with tonsil cells the sera reacted, by direct and indirect immunofluorescence, with phagocytic mononuclear cells from a variety of tissues and, in addition, stained a small population of nonphagocytic non‐T, non‐B mononuclear cells present in blood, spleen, and marrow but absent or very rare in tonsil and thymus. The antisera may define a human monocyte‐macrophage cell surface differentiation antigen (HuMA) and can be used to deplete or enrich reactive cell populations.