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Role of B Cells in the Expression of the PPD Response of Human Lymphocytes In Vitro
Author(s) -
BLOMGREN H.
Publication year - 1975
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1975.tb02655.x
Subject(s) - in vitro , biology , expression (computer science) , immunology , microbiology and biotechnology , genetics , computer science , programming language
Human blood lymphocytes were tested for their proliferative response to purified protein derivative (PPD) in vitro. Purified T cells showed a lower response than the original purified lymphocyte suspension Purified B cells were un responsive to PPD. Mixtures of preparations of T and B tells were stimulated to a greater extent by this antigen than anticipated by adding the responses of the two cell types tested separately. This cell synergy could largely be explained by soluble factors released by PPD‐stimulated T cells, which were found to be mitogenic for B cells.