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Reduced Capacity to Produce Specific ‘Effector’ Cells after Injection of CBA Mice with C3H Cells
Author(s) -
LILLIEHÖÖK B.,
JACOBSSON H.,
BLOMGREN H.
Publication year - 1975
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1975.tb02651.x
Subject(s) - spleen , effector , biology , immunology , c57bl/6 , antigen , population , graft vs host reaction , lymph node , lymphocyte , microbiology and biotechnology , bone marrow , medicine , bone marrow transplantation , environmental health
Lymphocytes from mice of strain CBA are strongly MLC‐responsive to lymphocytes from the H‐2 compatible‐ but M‐antigen‐incompatible strain C3H. This strong reactivity disappears after infusion of CBA mice with C3H lymphocytes. This study shows that the host‐versus‐graft reactivity (swelling of local lymph node after antigen injection) is specifically reduced after injection of CBA mice with C3H × CBA spleen cells However, lymphocytes from such mice showed a specifically increased GVH reactivity (inhibition of erythroid cell growth) compared with lymphocytes from unimmunized mice. Lymphocytes from normal CBA mice showed a high proliferative rate in the spleens of irradiated C3H × CBA mice. Such ‘educated’ cells showed strongly increased specific GVH reactivity. Lymphocytes from CBA mice previously injected with C3H×CBA cells showed reduced capacity to proliferate when injected into irradiated C3H × CBA hybrids and a poor capacity to develop new ‘effector’ cells reactive against C3H × CBA bone marrow target cells. The results indicate that the presence of specifically ‘MLC responsive’ lymphocytes in a lymphoid cell population is a prerequisite of its production of ‘effector’ cells able to respond in this GVH assay