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H‐2 Private Specificity of In VivoSensitized Lymphocytes Studied by Adsorption on Fibroblast Monolayers
Author(s) -
JØRGENSEN P. N.,
GÜTTLER F.,
RUBIN B.
Publication year - 1975
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1975.tb02640.x
Subject(s) - monolayer , fibroblast , adsorption , chemistry , microbiology and biotechnology , biology , biochemistry , in vitro
Spleen cells or thymocytes immune to one H‐2 genotype are cytotoxic to allogeneic target cells of a third‐party genotype, provided the target shares private specificities determined by either the H‐2K or the H‐2D locus of the H‐2 complex with the H‐2 genotype used for sensitization in vivo. The present results on elimination of cytotoxicity to specificities determined by one of the H‐2 loci after adsorption of the immune lymphoid cells onto fibroblasts bearing this specificity suggest a state of diversity among effector lymphocytes reactive to the antigens determined by either the H‐2K or the H‐2D locus of the H‐2 complex. Thymus cells activated in vivo were less specifically adsorbable than spleen cells of tumor‐allografted mice.