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Genetic Control of the Murine Cell‐Mediated Immune Response In Vivo
Author(s) -
DAVIS S.
Publication year - 1975
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1975.tb02624.x
Subject(s) - congenic , spleen , immune system , in vivo , biology , allele , population , microbiology and biotechnology , immunology , lymphocyte , major histocompatibility complex , cell mediated immunity , mixed lymphocyte reaction , antigen , immunity , histocompatibility , t cell , genetics , medicine , gene , human leukocyte antigen , environmental health
Various inbred and congenic strains of mice were immunized with the linear terpolymer L‐glutamic acid 60 ‐L‐alanine 30 ‐L‐tyrosine 10 (GAT). Using a radioisotopic footpad assay to measure cell‐mediated immunity in vivo, mice with H‐2 a , H‐2 b , H‐2 d , and H‐2 k histocompatibility alleles showed a positive reaction, whereas mice with H‐2 P and H‐2 S alleles failed to respond. The ability of ‘responder’. lymphocytes to show an immune response resides in the thymus‐derived (T) lymphocyte population. Unfractionated spleen cells from H‐2 q nonresponder mice, on transfer, showed no reactivity, whereas T‐cell‐enriched preparations were active.