Premium
Nude Mouse Embryo: Ectodermal Nature of the Primordial Thymic Defect
Author(s) -
CORDIER A C,
HEREMANS J F.
Publication year - 1975
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1975.tb02616.x
Subject(s) - ectoderm , endoderm , embryo , embryology , histogenesis , biology , pouch , nude mouse , gestation , anatomy , andrology , endocrinology , embryogenesis , medicine , embryonic stem cell , pregnancy , microbiology and biotechnology , immunology , genetics , immunohistochemistry , in vitro , gene
Sterile female homozygous nude mice were rendered fertile through a graft of thymic epithelium from heterozygous littermates 3 days after birth Homozygous nude embryos were compared with embryos of comparable age (8‐18 days). In nude mice, the embryological anomaly is noticeable from the 11th day of gestation and essentially consists of a failure of the ectoderm from the 3rd branchial cleft to proliferate and differentiate into a cervical vesicle. As a result, the endoderm from the 3rd pouch degenerates into cystic formations instead of differentiating