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Genetic Control of B‐Cell Responses
Author(s) -
COUTINHO A.,
GRONOWICZ E,
SULTZER B. M.
Publication year - 1975
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1975.tb02610.x
Subject(s) - lipopolysaccharide , polyclonal antibodies , spleen , b cell , population , secretion , antibody , cell , microbiology and biotechnology , immunology , biology , chemistry , medicine , biochemistry , environmental health
Spleen cells from C3H/HeJ mice fail to develop both proliferative responses and increased polyclonal antibody secretion in the presence of concentrations of the B‐cell mitogen lipopolysaccharide that are optimal for the induction of B‐cell responses in conventional strains This unresponsiveness is selective for lipopolysaccharide, since C3H/HeJ spleen cells respond normally to two other polyclonal B‐cell activators–dextran‐sulphate and purified protein derivative of tuberculin. These findings are interpreted as indicating a selective defect in the B‐cell sub‐population that responds to lipopolysaccharides in conventional strains.