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The P‐Component of Amyloid of Human Islets of Langerhans
Author(s) -
WESTERMARK P,
SKINNER M,
COHEN A. S.
Publication year - 1975
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1975.tb02604.x
Subject(s) - serum amyloid p component , amyloid (mycology) , islet , immunodiffusion , amyloidosis , component (thermodynamics) , human liver , amyloid fibril , chemistry , pathology , endocrinology , immunology , biology , medicine , biochemistry , diabetes mellitus , antigen , amyloid β , enzyme , disease , physics , c reactive protein , inflammation , thermodynamics
The P‐component of amyloid was found in extracts of pancreases with islet amyloidosis. In double immunodiffusion this P component showed lines of identity with isolated purified human P‐component, normal human serum, and an extract of amyloid‐rich liver tissue from a patient with primary systemic amyloidosis. The finding supports the theory that the P‐component is present in all native human amyloid irrespective of type.