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Adenosine Deaminase in the Congenitally Immunodeficient Nude Mouse
Author(s) -
KORBER W.,
HERMANN G.
Publication year - 1974
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1974.tb01320.x
Subject(s) - adenosine deaminase , adenosine deaminase deficiency , immunodeficiency , isozyme , amp deaminase , severe combined immunodeficiency , adenosine , enzyme , medicine , biology , immunology , endocrinology , biochemistry , gene , immune system
Various cases of human combined immunodeficiency together with adenosine‐deaminase deficiency have been described in the last 3 years. The congenitally thymus‐less (nu/nu) mouse could be presumed to serve as a possible laboratory model for examination of this combination of enzymatic deficiency and immunodeficiency. The present investigations, however, show similar isozyme pattern and enzymatic activity of nude mice and healthy Balb/c and C3H mice. Adenosine‐deaminase deficiency cannot be the cause of the immunodeficiency of the nude mouse.