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Comparative Study of Antibody‐Dependent and Direct Lymphocyte‐Mediated Cytotoxicity In Vitro After Alloimmunization in the Human
Author(s) -
DICKMEISS E.
Publication year - 1974
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1974.tb01316.x
Subject(s) - cytotoxicity , cytolysis , in vitro , cytotoxic t cell , lymphocyte , effector , antibody , immune system , immunology , antibody dependent cell mediated cytotoxicity , chemistry , biology , biochemistry
Two major types of cell‐mediated cytotoxicity in vitro after alloimmunization in the human have been described–antibody‐dependent lymphocyte‐mediated cytotoxicity (ADLC) and direct immune‐lymphocyte‐mediated cytotoxicity (DEC) The characteristics of these two in vitro systems are compared. The cytolysis occurred as a linear function of time in both cases The effector cell dose response relationship was in both systems well described by a linear correlation between the logarithm of the effector cell dose and the cytotoxic activity. Anti‐immunoglobulins inhibited ADLC but not DLC. The reactivity in DLC was potentiated by the addition of isoantibody directed against target cells.