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Effect of Human Leukocyte Interferon on the Response of Lymphocytes to Mitogenic Stimuli In Vitro
Author(s) -
BLOMGREN H.,
STRANDER H.,
CANTELL K.
Publication year - 1974
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1974.tb01305.x
Subject(s) - phytohaemagglutinin , pokeweed mitogen , concanavalin a , in vitro , interferon , lymphocyte , phytohemagglutinins , biology , immunology , lymphocyte activation , mixed lymphocyte reaction , microgram , mitogen activated protein kinase , chemistry , microbiology and biotechnology , biochemistry , immune system , t cell
Partially purified human leukocyte interferon suppressed the in vitro response of human lymphocytes to phytohaemagglutinin. concanavalin A, and purified protein derivative and also the mixed lymphocyte reaction. The inhibitory effect correlated with concentration and was detectable at 10 units/ml of culture medium. The activation of lymphocytes by pokeweed mitogen was affected by interferon only in very high concentrations The data presented are considered to be of clinical importance, since the serum interferon levels in patients receiving therapy with such preparations exceed the concentrations required for detection of in vitro inhibition of mitogenic stimuli.