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Atypical Blood Lymphocytes in Sarcoidosis: Morphology, Cytochemistry, and Membrane Properties
Author(s) -
BIBERFELD P.,
HEDFORS E.
Publication year - 1974
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1974.tb01295.x
Subject(s) - cytochemistry , ultrastructure , pathology , peripheral blood mononuclear cell , biology , lymphocyte , sarcoidosis , atypical lymphocyte , immunology , peripheral blood , microbiology and biotechnology , medicine , in vitro , biochemistry
Atypical mononuclear cells in purified lymphocyte preparations from the peripheral blood of patients with sarcoidosis were characterized by ultrastructure. cytochemistry, and presence or absence of membrane receptors for activated complement (EAC + or EAC − ). The atypical cells did not show the cytochemical characteristics of monocytic cells, appeared to be either EAC + or EAC − . and were morphologically heterogeneous. By their ultrastructure and ability to form EAC rosettes, the atypical cells were differentiated as EAC − , Sézary‐cell‐like (type I); as EAC‐lymphoplasmacytoid (type II): or as belonging to a miscellaneous group of cells (type III) that showed various degrees of similarity with either type I or II cells but usually were EAC + . The observations are interpreted as to the presence in the blood of sarcoidosis patients of atypical lymphocytes of B‐ and possibly T cell origin in different developmental stages. It is suggested that these cells reflect immunological events involving both B‐ and T‐lymphocyte populations