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Induction of Anti‐Alloantibodies by Alloantibody Fragments
Author(s) -
BINZ H.
Publication year - 1974
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1974.tb01270.x
Subject(s) - isoantibodies , chemistry , antibody , isoantigens , microbiology and biotechnology , immunology , medicine , biology
Anti‐alloantibodies of anti‐(Lewis anti‐DA) specificity were successfully induced in (Lewis × DA)F 1 rats by the IgG fraction, F(ab') 2 , and Fab fragments of Lewis anti‐DA alloantibodies, Fc fragments as well as separated heavy and light chains from the same alloantibody failed to induce anti‐alloantibodies. The idiotypic determinant on alloantibodies seems to be related to a structure formed by the two polypeptide chains