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The Principle of Immunopotentiation in Treatment of Rheumatoid Arthritis: Effect of Transfer Factor
Author(s) -
FRØLAND S. S.,
NATVIG J. B.,
HØYERAAL H. M.,
KÅSS E.
Publication year - 1974
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1974.tb01252.x
Subject(s) - rheumatoid arthritis , immunology , medicine , synovitis , rheumatoid factor , in vivo , lymphocyte , immunity , arthritis , in vitro , antigen , immune system , biology , microbiology and biotechnology , biochemistry
Three patients (aged 3 to 7 years) suffering from active juvenile rheumatoid arthritis, with pronounced general illness, synovitis in multiple joints, and, two of them, typical fluctuating high fever, were treated with dialyzable transfer factor. During the treatment period, varying from 3 to 5 months, the patients received from 5 to 10 injections of transfer factor, each dose corresponding to the biological material obtained from 400 to 450 ml of normal blood. There was a marked improvement of the general condition, most pronounced in the two patients with the most severe disease, in whom the temperature was normalized. Joint functions also improved. There were changes in cell‐mediated immunity, with conversion of previously negative responses to antigens in delayed hypersensitivity in vivo and lymphocyte transformation in vitro. Lymphocyte transformation with unspecific mitogens and allogeneic lymphocytes, the proportions in peripheral blood of B and T lymphocytes, as well as Fc receptor‐bearing lymphocytes were normal and remained so during the observation period.