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On the Frequency of Valine in Position 2 of the V k III Subgroup
Author(s) -
SLETTEN K.,
HANNESTAD K.,
HARBOE M.
Publication year - 1974
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1974.tb01250.x
Subject(s) - valine , antiserum , precipitin , monoclonal antibody , microbiology and biotechnology , chemistry , monoclonal , amino acid , biology , antibody , biochemistry , immunology
An antiserum was developed with specificity for the V k III subgroup, as evidenced by a precipitin reaction with reference protein Man. The antiserum reacted specifically with 4 of 26 monoclonal IgM, 3 of 57 monoclonal IgG, and 2 of 44 monoclonal IgA immunoglobulins. N‐terminal amino acid sequence analysis was performed on kappa chains from 8 of these M‐components. All were found to belong to the V K III subgroup, and J of them had valine in position 2. This high frequency (37%) of valine in position 2 is discussed.