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Antibody‐Dependent Lymphocyte‐Mediated Cytotoxicity in an Allogeneic Human System
Author(s) -
DICKMEISS E.,
NIELSEN L. S.
Publication year - 1974
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1974.tb01248.x
Subject(s) - reactivity (psychology) , cytotoxicity , antibody , immunology , complement system , lymphocyte , complement (music) , in vitro , complement dependent cytotoxicity , chemistry , biology , medicine , antibody dependent cell mediated cytotoxicity , phenotype , biochemistry , pathology , alternative medicine , complementation , gene
The in vitro reactivity of human alloimmune sera against human lymphocytes in a complement‐dependent system is compared with the reactivity in a system based on the principle of antibody‐dependent lymphocyte‐mediated cytotoxicity (ADLC). The sensitivity by which ADLC detects antibody reactivity is a 100‐ to a 1000‐fold greater than the sensitivity of the complement‐dependent system. With a given serum, ADLC discloses reactivity against many more different lymphocytes than the complement‐dependent system. This substantially broader reactivity in ADLC is presumably caused by cross‐reactions in the HL‐A system.