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IgG1 Protein and Corresponding IgG1 Gene with the Genetic Gm Markers f, non a, and x
Author(s) -
NATVIG J. B.,
MICHAELSEN T. E.,
NIELSEN J. C.
Publication year - 1974
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1974.tb01240.x
Subject(s) - cistron , biology , gene , genetics , recombination , microbiology and biotechnology , escherichia coli
An IgGl type of protein with the genetic marker combination Gm(f), non a, and (x) has been described. The evidence from studies on isolated IgGl Fc fragments showed that the IgGl protein was of normal size. No Gm markers other than the three mentioned were found. Thus, there was no evidence for deletions or duplications giving rise to the unusual IgGl protein. In contrast, the origin of the unusual genetic marker combination appears to be a rare IgGl gene Gm f ,non a, x, probably due to an intragenic recombination at the IgGl cistron.