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Further Studies on the Mixed Leukocyte Reaction in Multiple Sclerosis and Various Arthritides
Author(s) -
HEDBERG H.,
KÄLLEN B,
LÖW B,
NILSSON O.
Publication year - 1973
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1973.tb02038.x
Subject(s) - multiple sclerosis , rheumatoid arthritis , medicine , immunology , disease , arthritis , pathology
The mixed leukocyte reaction (MLR) is impaired in multiple sclerosis and certain arthritides, notably rheumatoid arthritis. The present study shows that this phenomenon is not disease‐Specific: cells from patients with multiple sclerosis react poorly also with cells from patients with arthritis. A time study of the reaction excludes the possibility of an initial Strong MLR followed by cell death – a phenomenon sometimes seen in animal experiments. A study of the affect ot patient sera on a two‐way MLR between normal individuals shows that a small depressive effect is present with the patient sera, but this is not of the magnitude that it can explain the MLR impairment under study.