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Antibody‐induced Cell‐mediated Cytotoxicity in an Allogeneic Human System
Author(s) -
DICKMEISS E.
Publication year - 1973
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1973.tb02035.x
Subject(s) - antibody , cytotoxicity , cytotoxic t cell , cytochalasin b , immunology , effector , lymphocyte , complement system , chemistry , cell , microbiology and biotechnology , biology , in vitro , biochemistry
In a 51 Cr‐release assay system it is found that serum from normal women with pregnancy‐induced lymphocyte allo‐antibody can cooperate with normal non‐sensitized peripheral human leucocytic cells in producing cytotoxic activity against target cells from the husband. Conventional complement activation is not involved. The cooperating serum factor is found to be antibody and is located in the IgG fraction. The effector cells are lymphocytes and the activity is blocked by cytochalasin B.