Premium
Localization in Mouse Lymphoid Tissue of Receptors for Immunoglobulin
Author(s) -
THUNOLD S.,
TØNDER O.,
WIIG J. N.
Publication year - 1973
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1973.tb02024.x
Subject(s) - antibody , spleen , lymphatic system , receptor , lymph , microbiology and biotechnology , biology , antigen , lymphocyte , immunology , lymphatic tissues , immunoglobulin g , chemistry , pathology , medicine , biochemistry
Cryostat sections of mouse spleen and lymph nodes adsorbed sheep erythrocytes coated with rabbit or mouse IgG antibody. The reaction was mediated by the Fe part of the immunoglobulin molecule. Haemadsorption was inhibited by mouse IgG and antigen‐antibody complexes. Complement was not required. Sensitized erythrocytes failed to bind to thymus and to the thymus dependent areas of the peripheral lymphoid tissue. Results of Inhibition experiments with rabbit anti‐mouse lymphocyte serum and anti‐Θ serum further suggested that binding of sensitized erythrocytes to lymphoid tissue sections can be used as a marker for B lymphocytes.