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Effect of Anti Light‐Chain Antibodies on Rat Leukocytes in Vitro
Author(s) -
KOCH CLAUS,
NIELSEN HANS ERIK
Publication year - 1973
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1973.tb02009.x
Subject(s) - in vitro , antibody , microbiology and biotechnology , immunoglobulin light chain , lymphocyte , chemistry , receptor , thymidine , immunology , biology , biochemistry
The effect of the IgG fraction of rabbit anti rat L‐chain antibodies (aL) and their Fab fragments (Fab aL) on rat blood leukocytes cultured in vitro has been examined. Undigested aL increased the thymidine uptake in both mixed and unmixed leukocyte cultures over a very wide dose range. Fab aL had no effect on either mixed or unmixed leukocyte cultures. The nature of T lymphocyte receptors is briefly discussed.