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Oligoclonal Macroglobulinaemia
Author(s) -
HARBOE M.,
HANNESTAD K.,
SLETTEN K.
Publication year - 1972
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1972.tb03731.x
Subject(s) - homogeneous , antibody , immunoglobulin m , immunology , monoclonal antibody , cryoglobulins , monoclonal , antigen , medicine , immunoglobulin g , biology , mathematics , combinatorics
Ninety macroglobulinaemia sera were tested for occurrence of multiple monoclonal immunoglobulins. Thirteen (14%) of the sera contained more than one monoclonal immunoglobulin. The homogeneous macroglobulins were isolated from 3 sera; in each case individually specific antigenic determinants common to the two components were demonstrated, in addition to determinants unique for each component. NH 2 ‐terminal amino acid sequence studies in two patients showed that the IgM heterogeneity was due to differences in the primary structure of the variable parts of the μ (case Tö) and the μ (case æ) chains. Macroglobulinaemia appears to be a unique source of homogeneous immunoglobulins from related clones.