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Delayed‐Type Hypersensitivity in the Mouse
Author(s) -
COOPER M. G.
Publication year - 1972
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1972.tb01815.x
Subject(s) - flagellin , biology , salmonella , antigen , microbiology and biotechnology , immunology , genetics , bacteria
Delayed‐type hypersensitivity (DTH) to Salmonella polymerized flagellin (POL) was transferred to normal and lethally irradiated CBA mice by POL‐activated thymus‐derived (T) cells or by lymphoid cells rich in T cells from POL‐primed donors, but not by POL‐activated bone marrow‐derived (B) cells or by serum from POL‐primed donors. It was therefore concluded that T cells play a key role in the initiation of DTH reactions. T cells activated by POL of one specificity were equally able to transfer DTH to POL of the same or of another specificity. DTH to haemocyanin (HCY) ( Jasus lalandii ) was transferred only by HCY‐activated T cells. Two interpretations of these findings are discussed: 1) that T cells may be less restricted in specificity than B cells, and 2) that T cells recognize a common antigenic determinant (carrier determinant) on the polymerized flagellins of Salmonella spp , which is not recognized by B cells.