Premium
Delayed Hypersensitivity, Macrophage Migration, and Antibodies in Guinea‐Pigs Immunized with Diphtheria Toxoid
Author(s) -
KOSTIALA ANJA A. I.,
KOSUNEN T. U.
Publication year - 1972
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1972.tb00593.x
Subject(s) - diphtheria toxin , antibody , antitoxin , guinea pig , diphtheria , toxoid , immunization , immunology , adjuvant , titer , toxin , microbiology and biotechnology , virology , biology , vaccination , endocrinology
Guinea‐pigs were immunized with diphtheria toxoid (DT) or with DT‐anti‐toxin precipitate, both in Freund's complete adjuvant (FCA). DT‐induced inhibition of peritoneal cell migration was equally strong in both groups and increased with time after immunization. Some guinea‐pigs immunized with DT‐antitoxin precipitate were boosted with DT or DT‐antitoxin precipitate, both in FCA. This increased the antibody titre but did not affect 24‐hour skin reactivity or migration inhibition. Migration inhibition did not correlate with anti‐DT passive haemagglutinins, haemolysins, or cytophilic antibody on peritoneal cells, but did correlate with 24‐hour skin reactivity.