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REDOX regulation of mitochondrial function in plants
Author(s) -
GIRAUD ESTELLE,
VAN AKEN OLIVIER,
UGGALLA VINDYA,
WHELAN JAMES
Publication year - 2012
Publication title -
plant, cell and environment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.646
H-Index - 200
eISSN - 1365-3040
pISSN - 0140-7791
DOI - 10.1111/j.1365-3040.2011.02293.x
Subject(s) - biology , function (biology) , mitochondrion , gene , metabolite , translation (biology) , microbiology and biotechnology , regulation of gene expression , genetics , messenger rna , biochemistry
Mitochondrial components dynamically change in response to environmental and developmental cues. However, the regulatory pathways that underlie these changes are largely unknown. A global analysis of changes in mitochondrial components at the transcript, protein and metabolite levels was undertaken, to gain a greater insight into how mitochondrial functions are regulated and respond to various internal or external cues. At the transcript level, large‐scale changes in groups of genes suggest the presence of co‐regulatory mechanisms for these components. Furthermore, the pathways that regulate these changes appear to be integrated into regulatory pathways that alter a variety of functions in cells. However, the changes in transcripts are not always observed at the protein or the metabolite level. This is likely to be due to post‐transcriptional levels of regulation and also the fact that in‐depth profiles, which have been obtained for transcripts from a variety of studies, are currently not available for proteins and metabolites. Thus, while transcripts for genes give us a picture of what the cells are ‘thinking’ in relation to mitochondrial components, some of these responses may be lost in translation.