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Serological monitoring of protection of sheep against Echinococcus granulosus induced by the EG95 vaccine
Author(s) -
HEATH D. D.,
KOOLAARD J.
Publication year - 2012
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.2011.01341.x
Subject(s) - echinococcus granulosus , biology , serology , immunology , vaccination , antibody , echinococcosis , immunity , echinococcus , colostrum , immune system , zoology
Summary Although immunity to Echinococcus granulosus in sheep has been shown to be antibody‐mediated and complement‐dependent and can be passively transferred in colostrum, in animals vaccinated with EG95, the relationship between protection against an oral challenge infection with E. granulosus eggs and anti‐EG95 IgG ELISA absorbance values at the time of challenge has not been satisfactorily proven. Using a combination of results from three EG95 vaccination trials, we have found that the IgG ELISA absorbance at the time of challenge infection explains approximately 50% ( P ≤ 0·001) of the variability in the percentage protection against an oral challenge with E. granulosus eggs (transformed with arcsin).