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Influence of Echinococcus multilocularis infection on reproduction and cellular immune response of mice
Author(s) -
ANTOLOVÁ D.,
REITEROVÁ K.
Publication year - 2010
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.2009.01194.x
Subject(s) - biology , echinococcus multilocularis , immune system , reproduction , immunology , immunity , echinococcosis , zoology , ecology
Summary The influence of secondary Echinococcus multilocularis infection on reproduction and cellular immune response of mice was studied in BALB/c mice infected with 2000 E. multilocularis protoscoleces. Of the total infected mothers, 11·7% did not give birth and 10% of uninfected ones did not deliver. Both, healthy and infected mothers, produced on average 6–7 offspring per litter. The changes in production of seral IFN‐γ, TNF and IL‐10 did not significantly influence the course of gravidity. On the other hand, more intensive metacestode growth was observed after the delivery. This study confirmed the ability of host organism to adapt to severe damage caused by E. multilocularis, not only in normal conditions, but also during pregnancy.