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Regulatory T Cells in children with intestinal parasite infection
Author(s) -
GARCÍAHERNÁNDEZ M. H.,
ALVARADOSÁNCHEZ B.,
CALVOTURRUBIARTES M. Z.,
SALGADOBUSTAMANTE M.,
RODRÍGUEZPINAL C. Y.,
GÁMEZLÓPEZ L. R.,
GONZÁLEZAMARO R.,
PORTALESPÉREZ D. P.
Publication year - 2009
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.2009.01149.x
Subject(s) - biology , immunology , immune system , foxp3 , cd28 , il 2 receptor , intestinal parasite , cd8 , cd3 , parasite hosting , t cell , helminths , world wide web , computer science
Summary Chronic intestinal parasite infection can induce both persistent immune activation and defective responsiveness of T cells. This study aimed to assess the number and function of T regulatory (Treg) cells in children with intestinal parasite infection. We have studied the peripheral blood from 93 children, 53 of them parasitized with protozoa, helminths, or both; the remainder were non parasitized, healthy controls. The number and function of CD4 + CD25 high and CD4 + Foxp3 + cells were similar in parasitized and control children. In contrast, there was a significant increase in the levels of CD3 + CD69 + , CD4 + CTLA‐4 + , and CD8 + CD28 − T cells in helminth infected children. Moreover, some of these patients showed a diminished response to CD3/CD28 stimulation in comparison with the control children. Our data strongly suggest that whilst Treg cells are not affected by intestinal parasite infection, CD3 + CD69 + , CD4 + CTLA‐4 + and CD8 + CD28 − lymphocytes may play an important, but as yet undetermined role in the diminished immune competence observed in parasitized children.