Premium
Imaging T‐cell movement in the brain during experimental cerebral malaria
Author(s) -
ORTOLANO F.,
MAFFIA P.,
DEVER G.,
HUTCHISON S.,
BENSON R.,
MILLINGTON O. R.,
DE SIMONI M. G.,
BUSHELL T. J.,
GARSIDE P.,
CARSWELL H. V.,
BREWER J. M.
Publication year - 2009
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.2008.01090.x
Subject(s) - cerebral malaria , neuroscience , biology , malaria , neuroimaging , pathology , immunology , plasmodium falciparum , medicine
SUMMARY T‐cells are known to play a role in the pathology associated with experimental cerebral malaria, although it has not previously been possible to examine their behaviour in brain. Using multiphoton laser scanning microscopy, we have examined the migration and movement of these cells in brain tissue. We believe that this approach will help define host–parasite interactions and examine how intervening in these relationships affects the development of cerebral pathology.