Premium
Selenium supplementation enhances the protective response to Toxocara canis larvae in mice
Author(s) -
PILARCZYK B.,
DOLIGALSKA M. J.,
DONSKOWSCHMELTER K.,
BALICKARAMISZ A.,
RAMISZ A.
Publication year - 2008
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/j.1365-3024.2008.01039.x
Subject(s) - toxocara canis , canis , eosinophil , biology , toxocariasis , immune system , immunology , intraperitoneal injection , pharmacology , helminths , ecology , asthma
SUMMARY The effect of oral and intraperitoneal supply of sodium selenite on the immune response to, and the course of T. canis larvae infection in mice were determined. The number of worms in the host tissue was reduced but the migratory route of larvae was not affected. Selenite (Se) supplementation influences Se retention in the liver, enhanced IL‐5 and eosinophil responses and evoked IL‐6 production in mice infected with T. canis . The enhanced protection in mice given Se intraperitoneally was associated with high levels of parasite‐specific IgE, and enhanced concentration of Th1‐related cytokines such IL‐12p70, TNF‐α and IFN‐γ. In mice given Se orally, the predominant cytokines produced were IL‐10, MCP‐1 and IL‐6 and these mice had lower protection. In conclusion, Se supplementation increases production of specific cytokines in mice infected with T. canis and increases protection against infection.